The researchers found biomarkers to predict the signs of fetal death in the first trimester, including a fifth previously unknown blood substance called verruculotoxin.
New biomarkers found in maternal blood could help doctors stop the baby’s death, researchers said. Lead author David Wishart said, “When we started to analyze the blood of women with dead children and compare them to healthy women, we found that there was a chemical difference, which suggests that we predict the birth of dead babies and possibly prevent it. “
Using a mass spectrometer, Wishart and his colleagues examined maternal blood and identified four chemicals that were consistently present in mothers who had a dead baby.
In combination with maternal demographic information, researchers found biomarkers that predict the signs of fetal death in the first trimester, including a fifth unknown blood chemical called verruculotoxin.
“Verrucotoxin is probably produced by microbes and fungi.” This is fascinating because there is anecdotal information about people who live in certain areas where there are heavy molds with a high stillbirth rate, “explains Wishart.
With this approach, scientists could develop tools and technologies to detect other preventable diseases that affect both women and children, he added.
Wishart also said, “This research is the tip of a larger iceberg.” By looking at the chemicals in the mother’s blood, we can not only recognize the risk of fetal death but also other conditions for the baby, mother and for the fetus. “
By focusing on the chemicals in the body, scientists have a clearer view of the causes and possible causes. It also opens up the possibility of applying this technique to other conditions related to the risk that can occur during pregnancy. Full results are available in the Journal of Maternal-Fetal and Neonatal Medicine.